In this talk, I will review recent progress on the application of cellular flow simulations (with the HemeLB flow solver) to characterise red blood cell (RBC) dynamics in complex vascular networks. First, I will demonstrate an intriguing association between reduced RBC flow and vascular remodelling during vascular development. Second, I will present two recently published studies relating vascular phenotypes encountered in the tumour microenvironment with anomalous RBC transport and potential tumour tissue hypoxia, a mechanism previously unreported. Finally, I will outline future research directions related to predicting vascular network function from its structure and how this can become a tool for biomedical investigation and eventually clinical translation.

# Minisymposia: MS03

#### Tuesday, July 18 at 10:30am

# Minisymposia: MS03

##### MS03-CARD-1:

Integrating Mathematics Across the Cardiovascular System: A Mini-Symposium on Multilevel Modelling of Cardiovascular Biology

**Organized by:** Jessica Crawshaw, Vijay Rajagopal, Michael Watson, Mitchel Colebank, Seth Weinberg

Note: this minisymposia has multiple sessions. The other session is **MS04-CARD-1**.

**Miguel Bernabeu***The University of Edinburgh (The Bayes Centre)*

"Red blood cell dynamics in complex vascular networks: implications in development and disease"**Mette Olufsen***North Carolina State University (Mathematics)*

"Multiscale approach for assessment of hemodynamics in Pulmonary Hypertension"**Fabian Spill***University of Birmingham (Mathematics)*

"The Human Cardiac Age-OME: Multi-omics analysis and mechanistic modelling of the ageing heart"

##### MS03-CDEV-1:

Data-driven, modeling, and topological techniques in cell and developmental biology

**Organized by:** Alexandria Volkening, Andreas Buttenschoen, Veronica Ciocanel

Note: this minisymposia has multiple sessions. The other session is **MS04-CDEV-1**.

**Dhananjay Bhaskar***Yale University (Department of Genetics)*

"Analyzing Spatiotemporal Signaling Patterns using Geometric Scattering and Persistent Homology"**Keisha Cook***Clemson University (School of Mathematical and Statistical Sciences)*

"Predictive Modeling of the Cytoskeleton"**Calina Copos***Northeastern University (Biology and Mathematics)*

"From microscopy to the distribution of mechanochemical efforts across a pair of cells"**Daniel A. Cruz***University of Florida (Department of Medicine)*

"Topological data analysis of pattern formation in stem cell colonies"

##### MS03-CDEV-2:

Polarity and patterns meet biophysical and biochemical dynamics

**Organized by:** Adriana Dawes, S. Seirin-Lee

**Adriana Dawes***The Ohio State University (Department of Mathematics/Department of Molecular Genetics)*

"The interplay between biochemistry and geometry in polarization of the early C. elegans embryo"**Sungrim Seirin-Lee***Kyoto University (Kyoto University Institute for the Advanced Study of Human Biology (ASHBi))*

"Mind the gap: Space inside eggs steers first few steps of life"**Masatoshi Nishikawa***Hosei University (Department of Frontier Bioscience)*

"PAR polarization in less contractile cell"**Eric Cytrynbaum***The University of British Columbia (Mathematics)*

"Mechanisms and models of spatiotemporal patterns in reptile polyphyodont dentition"

##### MS03-ECOP-1:

Current trends in phylogenetics

**Organized by:** Kristina Wicke, Laura Kubatko

Note: this minisymposia has multiple sessions. The other session is **MS04-ECOP-1**.

**Hector Banos***Dalhousie University (Department of Mathematics and statistics)*

"When Are Profile Mixture Models affected by Over-parameterization?"**Peter Beerli***Florida State University (Scientific Computing)*

"Population genetics processes impact Species Trees estimation"**Lena Collienne***Fred Hutch Cancer Center (Computational Biology)*

"Spaces of Discrete Time Trees"**Tandy Warnow***University of Illinois Urbana-Champaign (Computer Science)*

"New methods for very-large scale maximum likelihood tree estimation"

##### MS03-ECOP-2:

Modeling and Analysis of Evolutionary Dynamics Across Scales and Areas of Application

**Organized by:** Daniel Cooney, Olivia Chu

Note: this minisymposia has multiple sessions. The other session is **MS04-ECOP-2**.

**Anuraag Bukkuri***Moffitt Cancer Center (Integrated Mathematical Oncology)*

"Evolution of Resistance in Structured Neuroblastoma Populations"**Olivia J. Chu***Dartmouth College (Mathematics)*

"An Evolutionary Game Theory Model of Altruism via Arrhenotoky"**Nicole Creanza***Vanderbilt University (Department of Biological Sciences)*

"Modeling and analysis of cultural evolution: insights from humans and birds"**Wai-Tong (Louis) Fan***Indiana University (Mathematics)*

"Stochastic waves on metric graphs and their genealogies"

##### MS03-EDUC-1:

Mathematical-biology education in a post-COVID world

**Organized by:** Stacey Smith?

Note: this minisymposia has multiple sessions. The other session is **MS04-EDUC-1**.

**Glenn Ledder***University of Nebraska-Lincoln (Mathematics)*

"Using NetLogo for Modeling of Virtual Worlds"**Dmitry Kondrashov***University of Chicago (Biological Sciences Collegiate Division)*

"Comparison of assessment and teaching modalities for a quantitative biology course"**Stacey Smith?***The University of Ottawa (Mathematics)*

"How getting cheaters to reflect on their actions turned my worst course into my best course"

##### MS03-IMMU-1:

Viral dynamics and its applications

**Organized by:** Tin Phan, Ruian Ke, Ruy M. Ribiero, Alan S. Perelson

Note: this minisymposia has multiple sessions. The other session is **MS04-IMMU-1**.

**Stanca Ciupe***Virginia Tech (Mathematics)*

"Mathematical models of Usutu Viral Infection"**Elissa Schwartz***Washington State University (Math/Biol Sci)*

"Equine Infectious Anemia Virus (EIAV) dynamics and applications to vaccine development"**Wenjing Zhang***Texas Tech University (Department of Mathematics and Statistics)*

"Detecting and Resetting Tipping Points to Create More HIV Post-treatment Controllers with Bifurcation and Sensitivity Analysis"**Jasmine A. F. Kreig***Los Alamos National Laboratory (T6: Theoreticacl Biology and Biophysics)*

"Using an agent-based model to explore affinity maturation of B cells: a SARS-CoV-2 case study"

##### MS03-MFBM-1:

Stochastic methods for biochemical reaction networks

**Organized by:** Wasiur KhudaBukhsh, Hye-Won Kang

Note: this minisymposia has multiple sessions. The other session is **MS04-MFBM-1**.

**Grzegorz A. Rempala***The Ohio State University (Biostatistics)*

"Agent-based, aggregated dynamics for chemical reaction networks"**Hye-Won Kang***University of Maryland, Baltimore County (Department of Mathematics and Statistics)*

"Stochastic oscillations in the enzyme-catalyzed chemical reaction network in glycolysis"**Yi Fu***University of California, San Diego (Bioinformatics and Systems Biology PhD Program)*

"Comparison Theorems for Stochastic Chemical Reaction Networks"**Arnab Ganguly***Louisiana State University (Mathematics)*

"Statistical inference of stochastic differential equations with applications to biochemical reactions"

##### MS03-MFBM-2:

Inference, analysis, and control of Boolean network models

**Organized by:** David Murrugarra

**Elena Dimitrova***California Polytechinc State University, San Luis Obispo (Mathematics)*

"A unified approach to reverse engineering and data selection for unique network identification"**Brandilyn Stigler***Southern Methodist University (Mathematics)*

"Computational Algebraic Methods for Boolean Network Modeling"**Claus Kadelka***Iowa State University (Department of Mathematics)*

"A modular design of gene regulatory networks emerges naturally in response to an evolutionary multi-objective optimization problem"**Daniel R. Plaugher***University of Kentucky (Department of Toxicology and Cancer Biology)*

"Phenotype control techniques for gene regulatory networks"

##### MS03-ONCO-1:

Dynamics of cellular heterogeneity: consequences of diverse regulatory mechanisms

**Organized by:** Mohit Kumar Jolly, Paras Jain

Note: this minisymposia has multiple sessions. The other session is **MS04-ONCO-1**.

**Amy Brock***University of Texas at Austin (Biomedical Engineering)*

"Heritability and plasticity of therapeutic resistance mechanisms within heterogeneous cancer cell populations"**Morgan Craig***Sainte-Justine University Hospital Research Centre / Université de Montréal (Immune Disorders and Cancer / Mathematics and Statistics)*

"Impact of cellular and spatial heterogeneity on immunotherapies to treat glioblastoma"**Yogesh Goyal***Northwestern University (Cell and Developmental Biology)*

"Tracing origin and consequences of rare cell plasticity in cancer drug resistance"**Geena Ildefonso***University of Southern California (Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA)*

"A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion"