In this talk, I will review recent progress on the application of cellular flow simulations (with the HemeLB flow solver) to characterise red blood cell (RBC) dynamics in complex vascular networks. First, I will demonstrate an intriguing association between reduced RBC flow and vascular remodelling during vascular development. Second, I will present two recently published studies relating vascular phenotypes encountered in the tumour microenvironment with anomalous RBC transport and potential tumour tissue hypoxia, a mechanism previously unreported. Finally, I will outline future research directions related to predicting vascular network function from its structure and how this can become a tool for biomedical investigation and eventually clinical translation.
Tuesday, July 18 at 10:30am
MS03-CARD-1: Integrating Mathematics Across the Cardiovascular System: A Mini-Symposium on Multilevel Modelling of Cardiovascular Biology
Organized by: Jessica Crawshaw, Vijay Rajagopal, Michael Watson, Mitchel Colebank, Seth Weinberg Note: this minisymposia has multiple sessions. The other session is MS04-CARD-1.
- Miguel Bernabeu The University of Edinburgh (The Bayes Centre) "Red blood cell dynamics in complex vascular networks: implications in development and disease"
- Mette Olufsen North Carolina State University (Mathematics) "Multiscale approach for assessment of hemodynamics in Pulmonary Hypertension"
- Fabian Spill University of Birmingham (Mathematics) "The Human Cardiac Age-OME: Multi-omics analysis and mechanistic modelling of the ageing heart"
MS03-CDEV-1: Data-driven, modeling, and topological techniques in cell and developmental biology
Organized by: Alexandria Volkening, Andreas Buttenschoen, Veronica Ciocanel Note: this minisymposia has multiple sessions. The other session is MS04-CDEV-1.
- Dhananjay Bhaskar Yale University (Department of Genetics) "Analyzing Spatiotemporal Signaling Patterns using Geometric Scattering and Persistent Homology"
- Keisha Cook Clemson University (School of Mathematical and Statistical Sciences) "Predictive Modeling of the Cytoskeleton"
- Calina Copos Northeastern University (Biology and Mathematics) "From microscopy to the distribution of mechanochemical efforts across a pair of cells"
- Daniel A. Cruz University of Florida (Department of Medicine) "Topological data analysis of pattern formation in stem cell colonies"
MS03-CDEV-2: Polarity and patterns meet biophysical and biochemical dynamics
Organized by: Adriana Dawes, S. Seirin-Lee
- Adriana Dawes The Ohio State University (Department of Mathematics/Department of Molecular Genetics) "The interplay between biochemistry and geometry in polarization of the early C. elegans embryo"
- Sungrim Seirin-Lee Kyoto University (Kyoto University Institute for the Advanced Study of Human Biology (ASHBi)) "Mind the gap: Space inside eggs steers first few steps of life"
- Masatoshi Nishikawa Hosei University (Department of Frontier Bioscience) "PAR polarization in less contractile cell"
- Eric Cytrynbaum The University of British Columbia (Mathematics) "Mechanisms and models of spatiotemporal patterns in reptile polyphyodont dentition"
MS03-ECOP-1: Current trends in phylogenetics
Organized by: Kristina Wicke, Laura Kubatko Note: this minisymposia has multiple sessions. The other session is MS04-ECOP-1.
- Hector Banos Dalhousie University (Department of Mathematics and statistics) "When Are Profile Mixture Models affected by Over-parameterization?"
- Peter Beerli Florida State University (Scientific Computing) "Population genetics processes impact Species Trees estimation"
- Lena Collienne Fred Hutch Cancer Center (Computational Biology) "Spaces of Discrete Time Trees"
- Tandy Warnow University of Illinois Urbana-Champaign (Computer Science) "New methods for very-large scale maximum likelihood tree estimation"
MS03-ECOP-2: Modeling and Analysis of Evolutionary Dynamics Across Scales and Areas of Application
Organized by: Daniel Cooney, Olivia Chu Note: this minisymposia has multiple sessions. The other session is MS04-ECOP-2.
- Anuraag Bukkuri Moffitt Cancer Center (Integrated Mathematical Oncology) "Evolution of Resistance in Structured Neuroblastoma Populations"
- Olivia J. Chu Dartmouth College (Mathematics) "An Evolutionary Game Theory Model of Altruism via Arrhenotoky"
- Nicole Creanza Vanderbilt University (Department of Biological Sciences) "Modeling and analysis of cultural evolution: insights from humans and birds"
- Wai-Tong (Louis) Fan Indiana University (Mathematics) "Stochastic waves on metric graphs and their genealogies"
MS03-EDUC-1: Mathematical-biology education in a post-COVID world
Organized by: Stacey Smith? Note: this minisymposia has multiple sessions. The other session is MS04-EDUC-1.
- Glenn Ledder University of Nebraska-Lincoln (Mathematics) "Using NetLogo for Modeling of Virtual Worlds"
- Dmitry Kondrashov University of Chicago (Biological Sciences Collegiate Division) "Comparison of assessment and teaching modalities for a quantitative biology course"
- Stacey Smith? The University of Ottawa (Mathematics) "How getting cheaters to reflect on their actions turned my worst course into my best course"
MS03-IMMU-1: Viral dynamics and its applications
Organized by: Tin Phan, Ruian Ke, Ruy M. Ribiero, Alan S. Perelson Note: this minisymposia has multiple sessions. The other session is MS04-IMMU-1.
- Stanca Ciupe Virginia Tech (Mathematics) "Mathematical models of Usutu Viral Infection"
- Elissa Schwartz Washington State University (Math/Biol Sci) "Equine Infectious Anemia Virus (EIAV) dynamics and applications to vaccine development"
- Wenjing Zhang Texas Tech University (Department of Mathematics and Statistics) "Detecting and Resetting Tipping Points to Create More HIV Post-treatment Controllers with Bifurcation and Sensitivity Analysis"
- Jasmine A. F. Kreig Los Alamos National Laboratory (T6: Theoreticacl Biology and Biophysics) "Using an agent-based model to explore affinity maturation of B cells: a SARS-CoV-2 case study"
MS03-MFBM-1: Stochastic methods for biochemical reaction networks
Organized by: Wasiur KhudaBukhsh, Hye-Won Kang Note: this minisymposia has multiple sessions. The other session is MS04-MFBM-1.
- Grzegorz A. Rempala The Ohio State University (Biostatistics) "Agent-based, aggregated dynamics for chemical reaction networks"
- Hye-Won Kang University of Maryland, Baltimore County (Department of Mathematics and Statistics) "Stochastic oscillations in the enzyme-catalyzed chemical reaction network in glycolysis"
- Yi Fu University of California, San Diego (Bioinformatics and Systems Biology PhD Program) "Comparison Theorems for Stochastic Chemical Reaction Networks"
- Arnab Ganguly Louisiana State University (Mathematics) "Statistical inference of stochastic differential equations with applications to biochemical reactions"
MS03-MFBM-2: Inference, analysis, and control of Boolean network models
Organized by: David Murrugarra
- Elena Dimitrova California Polytechinc State University, San Luis Obispo (Mathematics) "A unified approach to reverse engineering and data selection for unique network identification"
- Brandilyn Stigler Southern Methodist University (Mathematics) "Computational Algebraic Methods for Boolean Network Modeling"
- Claus Kadelka Iowa State University (Department of Mathematics) "A modular design of gene regulatory networks emerges naturally in response to an evolutionary multi-objective optimization problem"
- Daniel R. Plaugher University of Kentucky (Department of Toxicology and Cancer Biology) "Phenotype control techniques for gene regulatory networks"
MS03-ONCO-1: Dynamics of cellular heterogeneity: consequences of diverse regulatory mechanisms
Organized by: Mohit Kumar Jolly, Paras Jain Note: this minisymposia has multiple sessions. The other session is MS04-ONCO-1.
- Amy Brock University of Texas at Austin (Biomedical Engineering) "Heritability and plasticity of therapeutic resistance mechanisms within heterogeneous cancer cell populations"
- Morgan Craig Sainte-Justine University Hospital Research Centre / Université de Montréal (Immune Disorders and Cancer / Mathematics and Statistics) "Impact of cellular and spatial heterogeneity on immunotherapies to treat glioblastoma"
- Yogesh Goyal Northwestern University (Cell and Developmental Biology) "Tracing origin and consequences of rare cell plasticity in cancer drug resistance"
- Geena Ildefonso University of Southern California (Alfred E. Mann Department of Biomedical Engineering, University of Southern California, Los Angeles, California, USA) "A data-driven Boolean model explains memory subsets and evolution in CD8+ T cell exhaustion"