In this talk, I will review recent progress on the application of cellular flow simulations (with the HemeLB flow solver) to characterise red blood cell (RBC) dynamics in complex vascular networks. First, I will demonstrate an intriguing association between reduced RBC flow and vascular remodelling during vascular development. Second, I will present two recently published studies relating vascular phenotypes encountered in the tumour microenvironment with anomalous RBC transport and potential tumour tissue hypoxia, a mechanism previously unreported. Finally, I will outline future research directions related to predicting vascular network function from its structure and how this can become a tool for biomedical investigation and eventually clinical translation.
Cardiovascular Modelling Subgroup (CARD)
Ad hoc subgroup meeting room
(reserved for subgroup activities):
Brutus Buckeye Room in The Ohio Union
Jump to:
Sub-group minisymposia
MS03-CARD-1:
Integrating Mathematics Across the Cardiovascular System: A Mini-Symposium on Multilevel Modelling of Cardiovascular Biology
Organized by: Jessica Crawshaw, Vijay Rajagopal, Michael Watson, Mitchel Colebank, Seth Weinberg
Note: this minisymposia has multiple sessions. The other session is MS04-CARD-1.
- Miguel Bernabeu
The University of Edinburgh (The Bayes Centre)
"Red blood cell dynamics in complex vascular networks: implications in development and disease" - Mette Olufsen
North Carolina State University (Mathematics)
"Multiscale approach for assessment of hemodynamics in Pulmonary Hypertension" - Fabian Spill
University of Birmingham (Mathematics)
"The Human Cardiac Age-OME: Multi-omics analysis and mechanistic modelling of the ageing heart"
MS04-CARD-1:
Integrating Mathematics Across the Cardiovascular System: A Mini-Symposium on Multilevel Modelling of Cardiovascular Biology
Organized by: Jessica Crawshaw, Vijay Rajagopal, Michael Watson, Mitchel Colebank, Seth Weinberg
Note: this minisymposia has multiple sessions. The other session is MS03-CARD-1.
- Keith Chambers
University of Oxford (Wolfson Centre for Mathematical Biology, Mathematical Institute)
"Resolution vs chronic inflammation: A lipid/phenotype dual-structured model for early atherosclerosis" - Alys Clark
University of Auckland, New Zealand (Auckland Bioengineering Institute)
"The fetal circulation and its adaption to pathological placental development" - Joyce Lin
Cal Poly State University (Mathematics)
"Conduction reserve theory in cardiac tissue with reduced gap junction coupling" - Nicolae Moise
Ohio State University (Biomedical Engineering)
"Emergent Pacemaking and Tissue Heterogeneity in a Calcium Feedback Regulatory Model of the Sinoatrial Node"
Sub-group contributed talks
CT01-CARD-1:
CARD Subgroup Contributed Talks
- Erin Zhao
Indiana University-Purdue University Indianapolis
"Mathematical modeling of arterial occlusion" - Keshav Patel
University of Utah
"A Spatially Averaged Model for Platelet Cohesion by Von Willebrand Factor and Fibrinogen" - Michael Watson
University of New South Wales
"Journey to the Centre of the Plaque: A PDE Model of Necrotic Core Localisation in Atherosclerosis" - Solomon Feuerwerker
University of Vermont Larner College of Medicine
"Parsing the effects of differential programmed cell death pathways on plaque stability in atherosclerosis using an agent-based model"
CT02-CARD-1:
CARD Subgroup Contributed Talks
- Elisa Serafini
Houston Methodist Research Institute
"An Agent-Based Model of Cardiac Allograft Vasculopathy: towards a Cost-Effective Platform to Better Understanding Chronic Rejection Dynamics" - Pak-Wing Fok
University of Delaware
"Shear stress regulation in cylindrical arteries through medial growth and nitric oxide release" - Shake Ibna Abir
Western Kentucky University
"Deep Learning Application of Long Short-Term Memory (LSTM) to predict the risk factors of etiology cardiovascular disease."