MS06 - ONCO-1 Ohio Staters Traditions Room (#2120) in The Ohio Union
Integration of cellular processes in cell motility and cancer progression
Thursday, July 20 at 10:30am
Yangjin Kim, Magdalena Stolarska
Cancer is a complex, multi-scale process, in which genetic mutations occurring at a sub-cellular level manifest themselves as functional changes at the cellular and tissue scale. Both the immediate microenvironment (cell-cell or cell-matrix interactions) and the extended microenvironment (e.g. vascular bed, stromal cells) are considered major players in tumour progression as well as suppression. The microenvironment is known to control tumour growth and cancer cell invasion to surrounding stromal tissue. Therefore, a thorough understanding of the interaction of individual cells with the microenvironment would provide a foundation to generate new strategies in cancer treatments. In particular, understanding the effect of the microenvironment on the signal transduction pathways of individual cells can improve cancer therapies by allowing one to target the specific biochemical pathways that are associated with the disease. Therefore, the main aim of this session is to discuss current stages and challenges in modelling tumour growth and the development of therapeutic strategies. Specific goals of the session include: (i) analyzing both computational and analytical solutions to mathematical models of tumor growth and its mechanical and biochemical interaction with the microenvironment, (ii) improving our biochemical/biomechanical understanding of fundamental mechanism of cellular movement in the context of cancer progression, and (iii) suggesting possible laboratory experiments that allow us to better understand cellular processes and lead to the design of platforms for clinical diagnosis. The development of mathematical models and their analysis and simulation allows us to shed light on our understanding of tumour growth in the host tissue environment and on the biochemical and biomechanical interactions between players in cancer progression.