The control of cell proliferation—the central process in creating, maintaining, and regenerating tissues of defined sizes and shapes—is a tricky business, because proliferation is fundamentally autocatalytic, and therefore prone to instability. Yet multicellular organisms achieve great feats of speed, precision, and stability in the production and maintenance of tissues. Moreover, they do so in the face of considerable stochasticity in the outcomes of cell divisions. Experimental studies have identified generic strategies—all based on some form of collective integral feedback—that can be shown, mathematically, to achieve many of these control objectives. However, the reliance of such strategies on cell-cell interaction creates fragilities, arising from limits on the distances over which intercellular signals spread; limits on the time scales over which perturbations can be managed; and situational ultrasensitivity to stochastic fluctuations. I will discuss the tradeoffs these fragilities impose, and how they influence what control organisms can achieve safely. I will raise the possibility that such fragilities create opportunities for rare, stochastic progression to states of uncontrolled growth, i.e., cancer, and suggest that such transitions provide a better model for cancer initiation than current models based on genetic determinism.

# Minisymposia: MS07

#### Thursday, July 20 at 04:00pm

# Minisymposia: MS07

##### MS07-CDEV-1:

Computational models for developmental and cell biology: A celebration of the works of Prof. Ching-Shan Chou

**Organized by:** Wing-Cheong Lo, Weitao Chen, Wenrui Hao, Leili Shahriyari

Note: this minisymposia has multiple sessions. The other session is **MS06-CDEV-1**.

**Arthur D. Lander***University of California Irvine, Irvine, CA (Center for Complex Biological Systems, and Department of Developmental and Cell Biology)*

"Control and Stability in Proliferative Dynamics"**Dongbin Xiu***Ohio State University (Department of Mathematics)*

"Data driven modeling of partially observed biological systems"**Tau-Mu Yi***University of California, Santa Barbara (Molecular, Cellular, and Developmental Biology)*

"Systems Biology of Cell Polarity in Yeast"**Avner Friedman***Ohio State University (Department of Mathematics)*

"How breast cancer metastasize into the bone"**Chiu-Yen Kao***Claremont McKenna College (Mathematical Sciences)*

"Our math and biology journey: A tribute to Ching-Shan Chou"

##### MS07-CDEV-2:

Recent Studies on the Biomechanics and Fluid Dynamics of Living Systems: Cellular Biomechanics and Microfluidics

**Organized by:** Wanda Strychalski, Alexander Hoover

Note: this minisymposia has multiple sessions. The other session is **MS06-CDEV-2**.

**Hongfei Chen***Tulane University (Department of Mathematics)*

"Effects of Choanoflagellate Colony Shape on Hydrodynamic Performance"**Nigar Karimli***Indiana University-Purdue University Indianapolis (Mathematics)*

"A three-dimensional mathematical model of a viscoelastic osteocyte immersed in flow"**Sharon R. Lubkin***North Carolina State University (Mathematics)*

"Geometry, pattern, and mechanics of notochords"**Kendall Gibson***Tulane University (Mathematics)*

"Modeling the elastohydrodynamics of swimming choanoflagellates"

##### MS07-ECOP-1:

Microbial and ecological dynamics across the many natural scales

**Organized by:** Christopher Heggerud, Tyler Meadows

Note: this minisymposia has multiple sessions. The other session is **MS06-ECOP-1**.

**Kara Taylor***University of Florida (Department of Biology)*

"Simulating microbial metacommunities within the constraints of expected mean-variance relationships"**James Powell***Utah State University (Mathematics and Statistics)*

"Homogenization across scales reveals relative strengths of environmental and direct transmission of Chronic Wasting Disease in deer"**Chris Heggerud***UC Davis (Environmental Science and Policy)*

"A model free method of predicting transient dynamics."**Punit Gandhi***Virginia Commonwealth University (Department of Mathematics and Applied Mathematics)*

"Conceptual modeling of dryland vegetation patterns across timescales"

##### MS07-MEPI-1:

Recent advances in parameter identifiability of mathematical models in mathematical biology

**Organized by:** Omar Saucedo, Bren Case, Lauren Childs

Note: this minisymposia has multiple sessions. The other session is **MS06-MEPI-1**.

**Madeline A. E. Peters***Michigan State University (Microbiology and Molecular Genetics)*

"Challenges in forming inferences from limited data: a case study of malaria parasite maturation"**Bren Case***University of Vermont (Computer Science)*

"Restricted Marginal Divergence: an efficient Bayesian measure of practical identifiability for nonlinear systems in biology and epidemiology"**All Participants**

"Open Forum"

##### MS07-MEPI-2:

Disease Dynamics Across Scales

**Organized by:** Joshua Caleb Macdonald, Hayriye Gulbudak

Note: this minisymposia has multiple sessions. The other session is **MS06-MEPI-2**.

**Summer Atkins***Louisiana State University (Department of Mathematics and Statistics)*

"An immuno-epidemiological model of foot-and-mouth disease in African buffalo"**Leah LeJeune***Virginia Tech (Department of Mathematics)*

"Cross-immunity and transmission influences in a multistrain host-pathogen cholera model"**Alun L. Lloyd***North Carolina State University (Biomathematics Graduate Program and Department of Mathematics)*

"Spatial Spread of Dengue Virus: Appropriate Spatial Scales for Transmission"**Erin Gorsich***University of Warwick (Zeeman Institute for Systems Biology and Infectious Disease Epidemiology)*

"Modelling endemic Rift Valley fever virus"

##### MS07-NEUR-1:

Uncovering activity patterns, oscillations and other key dynamics of neuronal (and other) networks

**Organized by:** Cheng Ly, Janet Best, Pamela Pyzza, Yangyang Wang

Note: this minisymposia has multiple sessions. The other session is **MS06-NEUR-1**.

**Ngoc Anh Phan***University of Iowa (Department of Mathematics)*

"Robustness of mixed mode oscillations and mixed mode bursting oscillations in three-timescale neuronal systems."**Sushmita John***University of Pittsburgh (Mathematics)*

"Slow negative feedback enhances robustness of square-wave bursting"**Victoria Booth***University of Michigan (Mathematics)*

"Neural rhythms generated by spatially heterogeneous neuromodulation"**Fernando Antoneli***Universidade Federal de Sao Paulo (Centro de Bioinformatica Medica)*

"Network Dynamics: Theory and Examples"

##### MS07-NEUR-2:

Biological Networks Across Scales

**Organized by:** Richard Bertram

**Wilfredo Blanco Figuerola***State University of Rio Grande do Norte (Department of Computer Science)*

"Population Bursting in Modular Neural Networks"**Mehran Fazli***Henry M. Jackson Foundation for the Advancement of Military > Medicine, Inc., Bethesda, MD, USA (Austere Environments Consortium for Enhanced Sepsis Outcomes (ACESO))*

"Gene bundling: a new approach to clustering and reversed engineering of gene expression network"**Bhargav Karamched***Florida State University (Mathematics)*

"How do Heterogeneity and Correlated Information Affect Decision-Making in Social Networks?"**Brad Peercy***University of Maryland, Baltimore County (UMBC) (Mathematics and Statistics)*

"Loss of Synchrony to Silencing in Networks of Excitable Cells: Impact of Cell and Coupling Heterogeneity in Small Network Examples"

##### MS07-ONCO-1:

Integration of cellular processes in cell motility and cancer progression

**Organized by:** Yangjin Kim, Magdalena Stolarska

Note: this minisymposia has multiple sessions. The other session is **MS06-ONCO-1**.

**Magdalena Stolarska***Univeristy of St. Thomas (Mathematics)*

"On the significance of membrane unfolding and cortical stress generation in cell movement"**Jay Stotsky***University of Minnesota (School of Mathematics)*

"Cell Cortex Mechanics and Cell Swimming"**Donggu Lee***Konkuk University (Mathematics / Seoul, Republic of Korea)*

"Optimal strategies of oncolytic virus-bortezomib therapy"**Yangjin Kim***Konkuk University (Department of Mathematics)*

"Activated NOTCH induced monocyte recruitment suppresses anti-tumor immunity with virotherapy"

##### MS07-OTHE-1:

Modeling sex differences in health and disease

**Organized by:** Melissa Stadt

Note: this minisymposia has multiple sessions. The other session is **MS06-OTHE-1**.

**Melissa M. Stadt***University of Waterloo (Applied Mathematics)*

"Maternal calcium homeostasis: A mathematical analysis of the differential impacts of pregnancy and lactation"**Karin Leiderman***University of North Carolina at Chapel Hill (Mathematics, Computational Medicine)*

"Mathematical modeling to understand the effects of estrogen on platelet activation"**Tony Humphries***McGill University (Mathematics and Statistics)*

"Sex Specific Mathematical Modelling of Erythropoiesis"