James MacLaurin, Victor Matveev
Experimental evidence strongly suggests that stochasticity is widespread at the cellular level. There is a great need to understand how microscopic noise affects physiologically relevant cellular processes across scales, from the stochastic behavior of channels and receptors, to the stochastic dynamical phenomena guiding populations of cells such as tumors. The goal of this minisymposium is to bring together researchers exploring the role of stochasticity at diverse scales, with the goal of promoting the exchange of approaches and mathematical tools used to model and understand stochastic effects at different levels. For example, Gregory Conradi D. Smith (College of William & Mary) will present his work on how the stochastic allosteric binding of receptor dimers determines the activation properties of G-protein coupled receptors. Further, Martin Falcke (Max Delbrück Center, Berlin) will preset his latest research on how microscopic stochastic gating of single IP3 receptor-coupled channel organizes to produce collective channel opening events underlying cell-wide phenomena such as waves of calcium concentration. In his talk, Victor Matveev (NJIT) will compare the efficiency of modeling methods used to simulate stochastic neurotransmitter and hormone vesicle fusion, which is guided by stochastic calcium ion diffusion, buffering and binding. Finally, addressing the role of stochasticity at larger scales, Linh Huynh (University of Utah) will describe the role of stochastic effects in the tumor microenvironment on cancer cell dynamics.